FER
ZECEN
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SUMMARY AND EXPLANATION OF THE TEST
FER is a kind of soluble tissue protein to store iron in the body. Normal serum contains a small amount of FER. Serum iron levels decreased in acute anemia and pregnancy period, and elevated in acute and chronic liver damage and liver cancer. In recent years an acidic isoferritin is also found from liver cancer, called carcinoembryonic isoferritin, which may contribute to early diagnosis
FER concentration is very low in the blood. Iron content is about 1% in normal plasma. Serum Ferritin is in balance with the body storage, but it will vary with the amount of stored iron ion. In the earliest period of anemia and iron deficiency, Ferritin concentration in plasma decreased. This is much earlier than the changes of hemoglobin concentration, red blood cell size and total iron binding capacity. Therefore, serum ferritin can be used as an early indicator of iron deficiency. Meanwhile, large number of chronic conditions can lead to elevated serum Ferritin levels, including chronic infection, chronic inflammatory diseases such as rheumatoid arthritis, heart disease and other malignancies, especially lymphoma, leukemia, breast cancer and neuroblastoma, etc. Patients with these disorders always are accompanied by iron deficiency, but serum Ferritin level is normal. In patients with hepatitis or toxic liver damage, Ferritin levels elevated because Ferritin is released from damaged liver cells. In addition, Ferritin also rises for hemochromatosis and hemosiderosis.
FER, though not specific, but only elevated in liver cancer and pancreas cancer, and did not elevate in other gastrointestinal tumors such as esophageal cancer, stomach cancer, colorectal cancer. For Liver cancer patient, if therapeutically effective, Ferritin decreased, while for the deterioration and recurrence it will elevate. If it continued to increase, it indicates the prognosis is poor. Therefore, it can be used as one means of monitoring the efficacy, especially in patients who tested negative for FER.
FER is mainly used in dynamic monitoring with cancer and assists diagnosis of disease progression or therapeutic effect, but its concentration is not directly correlated with tumor size, growth, malignancy and grade/stage. For some benign diseases such as aplastic anemia, sideroblastic anemia, chronic hemolytic anemia, liver disease, myocardial infarction, acute infections, lead poisoning and anemia caused by a lack of vitamin B6 and so on, FER also rise. It cannot be used for cancer screening in the general population, especially early and definite diagnosis.
SUMMARY AND EXPLANATION OF THE TEST
FER is a kind of soluble tissue protein to store iron in the body. Normal serum contains a small amount of FER. Serum iron levels decreased in acute anemia and pregnancy period, and elevated in acute and chronic liver damage and liver cancer. In recent years an acidic isoferritin is also found from liver cancer, called carcinoembryonic isoferritin, which may contribute to early diagnosis
FER concentration is very low in the blood. Iron content is about 1% in normal plasma. Serum Ferritin is in balance with the body storage, but it will vary with the amount of stored iron ion. In the earliest period of anemia and iron deficiency, Ferritin concentration in plasma decreased. This is much earlier than the changes of hemoglobin concentration, red blood cell size and total iron binding capacity. Therefore, serum ferritin can be used as an early indicator of iron deficiency. Meanwhile, large number of chronic conditions can lead to elevated serum Ferritin levels, including chronic infection, chronic inflammatory diseases such as rheumatoid arthritis, heart disease and other malignancies, especially lymphoma, leukemia, breast cancer and neuroblastoma, etc. Patients with these disorders always are accompanied by iron deficiency, but serum Ferritin level is normal. In patients with hepatitis or toxic liver damage, Ferritin levels elevated because Ferritin is released from damaged liver cells. In addition, Ferritin also rises for hemochromatosis and hemosiderosis.
FER, though not specific, but only elevated in liver cancer and pancreas cancer, and did not elevate in other gastrointestinal tumors such as esophageal cancer, stomach cancer, colorectal cancer. For Liver cancer patient, if therapeutically effective, Ferritin decreased, while for the deterioration and recurrence it will elevate. If it continued to increase, it indicates the prognosis is poor. Therefore, it can be used as one means of monitoring the efficacy, especially in patients who tested negative for FER.
FER is mainly used in dynamic monitoring with cancer and assists diagnosis of disease progression or therapeutic effect, but its concentration is not directly correlated with tumor size, growth, malignancy and grade/stage. For some benign diseases such as aplastic anemia, sideroblastic anemia, chronic hemolytic anemia, liver disease, myocardial infarction, acute infections, lead poisoning and anemia caused by a lack of vitamin B6 and so on, FER also rise. It cannot be used for cancer screening in the general population, especially early and definite diagnosis.
